IRF5 and interstitial lung disease: However, the minor allele of two SNPs in IRF5 were more frequent in SSc patients without ILD than in controls, rs2004640 T allele (OR 1.39 (95% CI 1.11–1.75), pcorr = 0.03) and rs10488631 C allele (OR 1.72 (95% C 1.24–2.39), pcorr = 0.0098).