Also, Rogacev et al. have measured the serum level of PCSK9 in 2 independent cohorts: CARE FOR HOMe (Cardiovascular and Renal Outcome in CKD 2–4 Patients—The Forth Homburg evaluation), which included 443 patients, and the cohort LURIC (Ludwigshafen Risk and Cardiovascular Health Study) with 1450 patients [6], and they observed that plasma PCSK9 was poorly correlated with the total cholesterol, ApoB, and triglycerides [6]. The gene discussed is APOB; the disease is chronic kidney disease.