Along with DM, higher BMI, lower FGF-21 (P = 0.055), and higher AFABP, together with HOMA-IR levels (P < 0.001) showed correlation with more serious fibrosis/cirrhosis during antiviral therapy in people infected with CHB and received a 3.7-fold high risk of more serious fibrosis and cirrhosis [66]. The gene discussed is FGF21; the disease is fibrosis.