In Conti's study [23], the authors reported that both mRNA and cell surface expression of the signaling chain of the IFN-γ receptor (IFN-γR2) and its cognate tyrosine kinase JAK2 were enhanced in peripheral blood Th17 cells and clones from MS patients, compared to those with inactive multiple sclerosis or healthy controls. This evidence concerns the gene IFNGR2 and multiple sclerosis.