AKT1 and Myocardial fibrosis: Pathway enrichment analysis indicated that the inversely downregulated genes by QSG were mainly enriched in myocardial fibrosis, apoptosis, and inflammation related pathways, such as Hippo, ECM-receptor interaction, focal adhesion, Wnt, PI3K-AKT, chemokine, JAK-STAT, NF-κB, and TNF signaling pathways (Figure 6(a)); the inversely upregulated genes by QSG were mainly enriched in energy metabolism related pathways, such as PPAR, fatty acid metabolism, and fatty acid elongation signaling pathways (Figure 6(b)).