In addition, the expression level of exosomal miRNA is negatively correlated with creatinine level, bone marrow plasma cell load, and expression levels of serum factors such as β2-microglobulin and β-CTX (β-type I collagen carboxy-terminal peptide) in myeloma patients, suggesting that the expression level of miRNA in multiple myeloma exosomes is correlated with clinical manifestations of myeloma. Here, HLA-G is linked to plasma cell myeloma.