More interestingly, the PDGFR-beta signaling pathway has been implicated in familial idiopathic basal ganglia calcification, a brain disease characterized by anatomically localized calcifications in or near the blood microvessels (Betsholtz & Keller, 2014); hence, this pathway deserves further research, to comprehensively investigate its association with SCI-TBI-HO. This evidence concerns the gene PDGFRB and Basal ganglia calcification.