In conclusion, Wenxin granules can significantly improve the hemodynamics of MI rats and change the material properties of scar structure and residual myocardial structure, reduce the expression of type I and III collagen and increase the ratio of type I to type III collagen, and downregulate inflammatory stimulus signal TGFβ and reduce the phosphorylation level of p38/JNK. The gene discussed is TGFB1; the disease is myocardial infarction.