Peroxisome proliferator-activated receptor gamma (PPARG) is a ligand-activated transcription factor that plays an important role in the control of a variety of physiological processes such as metabolism, angiogenesis, fibrosis, inflammation, and oxidative stress in various blind-causing diseases, such as DR, age-related macular degeneration, and optic neuropathy [16–19]. The gene discussed is PPARG; the disease is optic nerve disorder.