In support of the protective role of Notch in the endothelium, Wang and collaborators reported that in bone marrow ECs, RBP-Jκ inhibits miR-155/NF-κB axis activation [251], data being reinforced by the Nus et al. study which showed that RBP-Jκ heterozygous inactivation results in aortic valve calcification under dyslipidemic condition [252]. This evidence concerns the gene RBPJ and aortic valve calcification.