INS and obesity due to melanocortin 4 receptor deficiency: Similarly, Miranda and collaborators, in an attempt to identify the link between the macrophage subtype and the resistance to insulin in HFD-induced obesity mouse models, found that miR-30, targeting Dll-4, is associated with obesity-induced inflammation and proinflammatory cytokine production in adipose tissue macrophages isolated from visceral fat of obese mice [283].