DLK1 and metabolic syndrome: Schober et al. showed instead that in aorta regions exposed to turbulent flow, thus prone to plaque formation, disturbed shear stress may lead to expression of the Notch inhibitor Delta-like 1 homolog (Dlk1), through the downregulation of miR126-5p, leading to reduced expression of HES5, a Notch-1 target gene essential for restoring the dyslipidemia-injured endothelium [257].