AKT1 and Parkinson disease: Chen et al. [200] demonstrated that TMP at different doses of 1, 3, and 10 mg/kg interfered with 6-ohda-induced Parkinson's disease in mice which confirmed that TMP protects against dopaminergic (DA) neurodegeneration and attenuates DA neuronal apoptosis by activating the PI3K/Akt/GSK3β signaling pathway.