AFP and hepatocellular carcinoma: The frequency of the rs2464196-AA+AG genotypes was significantly greater in the AFP ≤ 400 ng/ml group than in the AFP > 400 group (83.1% vs. 67.2%, P = 0.013), and the frequency of rs2464196-GG was significantly lower (16.9% vs. 32.8%, P = 0.013), suggesting that HCC patients carrying the rs2464196-A mutant allele were more likely to have a serum AFP concentration ≤ 400 ng/ml.