C1R and prion disease: In T3 vs. T2 group, the most upregulated protein is C9 in the pathways of Complement and coagulation cascades, Amoebiasis, Prion diseases, and Systemic lupus erythematosus, with complement factor H-related protein 1 (CFHR1) in Staphylococcus aureus infection pathway, complement C1r subcomponent (C1R) in Phagosome pathway, Ig alpha-2 chain C region (IGHA2) in Primary immunodeficiency, Dilated cardiomyopathy, and Fc gamma R-mediated phagocytosis pathways, and phospholipid transfer protein (PLTP) in PPAR signaling pathway.