In T3 vs. T1 group, the most upregulated protein was vitamin K-dependent protein C in the pathway of Complement and coagulation cascades with KRT16 in Staphylococcus aureus infection and Pathogenic Escherichia coli infection pathways, histone H4 (HIST1H4A) in Systemic lupus erythematosus pathway, IGHG4 in Phagosome and Primary immunodeficiency pathways, VWF in Focal adhesion pathway, hemoglobin subunit alpha (HBA1) in Malaria pathway, and apolipoprotein C-III (APOC3) in PPAR signaling pathway. The gene discussed is KRT16; the disease is escherichia coli infection.