The most downregulated protein is THBS1 in Phagosome and Focal adhesion pathways, with C4A in Complement and coagulation cascades and Staphylococcus aureus infection pathways, ITGA2B in Hematopoietic cell lineage pathway, alpha-actinin-1 (ACTN1) in Systemic lupus erythematosus pathway, myosin-9 (MYH9) in Regulation of actin cytoskeleton pathway, TPM4 in Dilated cardiomyopathy pathway, tubulin alpha-4A chain (TUBA4A) in Pathogenic Escherichia coli infection pathway, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in Metabolic pathway. The gene discussed is GAPDH; the disease is dilated cardiomyopathy.