In T1 vs. C group, the most downregulated protein was keratin, type I cytoskeletal 16 (KRT16) in Pathogenic Escherichia coli infection and Staphylococcus aureus infection pathways with 14-3-3 protein epsilon (YWHAE) in Cell cycle, Neurotrophin signaling pathway, and Oocyte meiosis pathway, von Willebrand factor (VWF) in Focal adhesion pathway, and Immunoglobulin heavy variable 2-26 (IGHV2-26) in the pathways of Phagosome, Viral myocarditis, and Systemic lupus erythematosus. The gene discussed is VWF; the disease is escherichia coli infection.