In short, this study used the combination of Chinese and Western medicine and by experimentation proved that Siwu granules combined with EPO significantly upregulated the EPO/EPOR signal, so that Siwu granules and EPO together can play a more powerful function as antioxidative damage, anti-inflammation, and antirenal fibrosis, and synergistically ameliorated anemia in adenine-induced chronic renal failure rats. Here, EPOR is linked to fibrosis.