Li et al., however demonstrated that KCNQ1OT1 downregulation attenuated myocardial ischemia/reperfusion injury from acute myocardial infarction, possibly by regulating adiponectin receptor 1 (AdipoR1)-p38 /NF-κB signaling cascade [28]. The gene discussed is KCNQ1OT1; the disease is myocardial ischemia.