In 2004, Kim et al. first introduced molecular markers into prognostic model of ccRCC [10], which based on a combination of clinical and molecular predictors included metastasis status, T stage, Eastern Cooperative Oncology Group performance status, as well as immunohistochemically staining of p53, CA9, and vimentin. The gene discussed is CA9; the disease is nonpapillary renal cell carcinoma.