It should be noted that another study found no changes in AD biomarkers in CSF, including Aβ species, t-tau, and phospho-tau, following recurrent partial sleep restriction (to 4 hours/night) in healthy young individuals.28 This suggests that changes may depend on a variety of factors, such as participant characteristics (including age), as well as the type, acuteness, and cumulative duration of sleep loss. Here, MAPT is linked to Alzheimer disease.