The exacerbated muscle wasting observed in mHCT116 tumor hosts was accompanied by increased circulating IL6, phosphorylated STAT3, E3 ubiquitin ligases and total ubiquitin, as well as reduced mitochondrial proteins, thereby suggesting that formation of LM in CRC is contributing to muscle wasting via multiple avenues. The gene discussed is STAT3; the disease is colorectal carcinoma.