The data presented in the current study support the notion that formation of LM, as occurring in CRC, may further perturb the hepatic production of IGF1 and IL6, thus exacerbating the potential for muscle wasting (Norris et al., 2014; Bonetto et al., 2012, 2011; Ueda et al., 1994; Baltgalvis et al., 2009; White et al., 2013). Here, IGF1 is linked to colorectal carcinoma.