IL6 and cancer: Two hepatokines known to play a role in skeletal muscle homeostasis and pathogenesis of multiple diseases, including cancer cachexia, are the anabolic factor IGF1 and the catabolic factor IL6 (Song et al., 2013; Attard-Montalto et al., 1998; Bonetto et al., 2013; Costelli et al., 2006; Cho et al., 2013; Huber et al., 2018).