Interestingly, no changes in the phosphorylation of the IGF1-dependent signal transducer AKT (also known as Akt1), as well as of ERK1/2 (Mapk3/Mapk1) and p38 (Ahsa1) were observed in the skeletal muscle of tumor-bearing animals relative to the respective controls (Fig. 4). Here, IGF1 is linked to neoplasm.