Given that the animals implanted with HCT116 tumors saw a reduction in muscle weight, we sought to assess the circulating levels of known regulators of muscle mass in CRC cachexia, e.g. IGF1 and IL6 (Bonetto et al., 2013, 2012; Costelli et al., 2006; Hetzler et al., 2015; White et al., 2013). Here, IGF1 is linked to colorectal carcinoma.