Perhaps of greater interest than the elevation in protein catabolism markers are the differential changes seen in mitochondrial proteins in the two tumor contexts, whereby HCT116 subcutaneous xenografts saw no alteration within the measured mitochondrial proteins and mHCT116 LM hosts saw reductions in PGC1α, OPA1, mitofusin 2, and cytochrome-C. The gene discussed is PPARGC1A; the disease is neoplasm.