In summary, the present study convincingly expanded the spectrum of anti-HMGCR myopathy to include isolated hyperCKemia, demonstrated the efficacy of steroid-free induction strategies in selected patients, validated the proposed Triple steroid/IVIG/SSI induction strategy, and confirmed that steroid-free maintenance is an achievable goal, occasionally through the use of SSI combinations or an SSI/IVIG maintenance. This evidence concerns the gene HMGCR and myopathy.