HMGCR and myopathy: The 224th ENMC definition of severe anti-HMGCR myopathy was the presence of walking difficulties and/or dysphagia, while partial remission was defined as an improvement ≥ 110% of MMT-8 and/or CK levels, the latter remaining greater than or equal to twice the normal range, i.e., ≥ 500 UI/L [16].