IGKV2D-24 and Cognitive impairment: Second, it is generally agreed that acupuncture and EA can attenuate cognitive deficits by means of inhibiting the neuronic peroxidatic reaction with the hippocampal tissue and attenuating the inflammation in the central and peripheral nervous systems [30], and one of the major pathways is the cholinergic anti-inflammatory pathway (CAP), which depends on the α7 subunit of the acetylcholine receptor (AChR) on macrophages and other cells [31].