In this study, we are trying to explore the role of SOD2 in CIH induced PH model by using SOD2-defected mice, pulmonary molecular mechanisms involved, specially NLRP3, from the aspect of myeloid immune response about how SOD2 act on vascular remodeling under CIH condition as a possible explanation for OSA-induced pulmonary hypertension. This evidence concerns the gene SOD2 and pulmonary arterial hypertension.