EZH2 and posterior cortical atrophy: As we would expect, our Gene Set Enrichment Analysis (GSEA) of robustly hypermethylated genes revealed relationships with histone modification H3K27me3 and the protein SUZ12, which is a partner of EZH2 (repeatedly reported to play a role in PCa development and progression) in PRC2, and its overexpression is also known to be involved in carcinogenesis [39–43].