CD8A and metastatic colorectal cancer: Based on the collective knowledge of the underlying biology, the model represents the primary CD8 + T cell response under a boosting effect of IL-12 and OXP and the subsequent impact on the growth of a tumor based on the syngeneic MC38Luc1 mouse model for metastatic colorectal cancer, where the observed response was characterized by three phenotypes: responders, partial responders, and non-responders.