We assume that IFNγ is secreted solely by effector CD8 + T cells within the tumor with stimulation from IL-12 and inhibition from regulatory T cellsat a rate of \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$c_{4}\cdot \frac {\text {IL}}{\text {IL}+g_{7}}\cdot \frac {T_{E3}}{T_{R}+g_{8}}$\end{document}c4·ILIL+g7·TE3TR+g8 [41]. This evidence concerns the gene CD8A and neoplasm.