Intriguingly, the hnRNPA1 PrLD (which overlaps with its M9 nuclear localization signal) is targeted by autoantibodies in MS patients [65], and hnRNPA1 mislocalizes to the cytoplasm and aggregates in patients with MS [66], similar to observations in hnRNPA1-linked prion-like disorders [33]. This evidence concerns the gene HNRNPA1 and myeloid sarcoma.