HNRNPA1 and chronic progressive multiple sclerosis: For example, in addition to hnRNPA1 mutations linked to prion-like disorders (which are also detected in our analysis; Fig. 3, and Additional file 3), K277 N, P275S, and P299L mutations in the hnRNPA1 PrLD increase its predicted aggregation propensity yet are associated with chronic progressive multiple sclerosis (Additional file 3), which is currently not considered a prion-like disorder.