LEP and Obesity: Although the LEP promoter polymorphism G‐2548A (rs7799039) has been studied intensively (De Silva et al., 1999; Duarte, Colagiuri, Palu, Wang, & Wilcken, 2003; Furusawa et al., 2011; Paracchini, Pedotti, & Taioli, 2005; Wang et al., 2006), the results for the associated single‐nucleotide polymorphism (SNP) and their alleles, which may indicate the roles of genetic and environmental factors in obesity, have been controversial.