The majority of cases are caused by genetic mutations, and to date, mutations in the MSX1, PAX9, AXIN2, WNT10A, EDA, EDAR, EDARADD, WNT10B and LRP6 genes have been associated with non-syndromic tooth agenesis (NSTA) cases [14–22]. This evidence concerns the gene MSX1 and tooth agenesis.