Some trends of aberrant immunity such as increase in BD-2, prodromal to TV infection (top quartile 2.99, 1–9), and reduced IL-1RA:IL-1β (bottom quartile OR 3.06, 1.37–6.84), prodromal to candida, persisted or exacerbated after the onset of these CVIs (top quartile OR for BD-2 7.89, 1.01, 61.64 in prevalent TV, and top quartile OR for IL-1RA:IL-1β 0.40, 0.19–0.84 in prevalent candida) suggesting that innate immunity state preceding infection may contribute to inflammation and risks associated with these prevalent CVIs. Here, IL1B is linked to infection.