In this study, each CVI was associated with a distinct prodromal state of cervical innate immunity, with higher BD-2 shared by imminent BV, CT, and herpes, reduced IL-1RA:ILβ shared by imminent intermediate Nugent score and candida, while higher IL-1β and lower VEGF, SLPI, and ICAM-1 being uniquely precursory for intermediate Nugent score, NG, candida, and TV, perhaps reflecting distinct pathogenic traits of vegetative bacterial, invasive bacterial, fungal and extracellular parasitic infections, respectively. Here, ICAM1 is linked to bacterial vaginosis.