Top quartile levels of the same 10 individual immune mediators tended to convey a negative predictive value (LR <1) for all STIs, which reached significance for select markers predicting incident CT (IL-6) and HSV-2 (IL-6, SLPI and ICAM-1 (LR = 0.10–0.04, p<005). This evidence concerns the gene ICAM1 and sexually transmitted disease.