Endothelial protein C receptor, Activated Protein C half-life, protein Z, fibrinolysis, factor XIII, intravascular heparin-like molecules are also decreased.[11–13] Increased D-dimer values on admission was reported to be relative to venous thromboembolism onset and it was taken for an independent predictor associated with venous thromboembolism in hospitalized IBD patients.[14] In the case we reported, markedly increased D-dimer (3.037 mg/L) were observed. This evidence concerns the gene TMBIM4 and venous thromboembolism.