Also, treatment of CXCL9 could dose-dependently reduced the mRNA expression and secretion of anti-tumour cytokines from CD8+ cytotoxic T cells, including TNFα, IL2, and IFNγ, further proving that CXCL9 treatment could lead to cytotoxic T cell exhaustion and dysfunction. Here, CXCL9 is linked to neoplasm.