Co-expression network between differentially-expressed lncRNAs and ECM-related factors was constructed and lncRNA Homo sapiens ring finger protein 7 variant 5 and variant 6 (lnc RNF7), which was conservative in rat, mouse, and human, was selected and examined for its effects on CF in vivo and in vitro. Here, RNF7 is linked to cystic fibrosis.