In the present study, microarray profiling analyses identified a total of 294 differentially-expressed mRNAs in CF and normal rat hearts, most of which were enriched in TGFβ signaling pathway and the extracellular matrix (ECM) receptor interaction (Itga11, Col2a1, Tnr, Thbs4, Thbs1, Sv2c, Comp). This evidence concerns the gene COL2A1 and cystic fibrosis.