APEX1 and neoplasm: In more than 11,000 tumor sample datasets, we observed that the gene expression correlation between APE1 and its PPI-network elements is higher (p-value < 1015) than that with respect to: (i) all the genes, (ii) random-gene datasets (PPI size) or iii) random genes vs the APE1-PPI network (Fig. 4A,B).