However, differently of offspring from obese dams (HFD-O) explored in this manuscript, Li and colleagues28 demonstrated that HFD-fed WT mice presented increased liver expression of α7nAChR over the period fed with HFD (8 weeks), implicating α7nAChR in the development of non-alcoholic fatty liver disease (NAFLD). Here, CHRNA7 is linked to metabolic dysfunction-associated steatotic liver disease.