TEAD1 and cancer: Furthermore, when we compared the MAP4K4 knockdown signature with gene dependency data from Project Achilles, a large-scale project involving genome-scale loss-of-function fitness screens performed in hundreds of cancer cell lines (Aguirre et al., 2016; Meyers et al., 2017; Tsherniak et al., 2017), we observed significant association with dependency profiles of TAZ1 and TEAD1 (IC = −0.447,–0.512, p-value=0.0001, 0.0001, respectively), which are both Hippo pathway effector molecules (Figure 8D).