The elevation of CSF pro‐inflammatory cytokine IL‐6, TNF, and IFN‐γ and anti‐inflammatory cytokine IL‐10 was approved in EVM,14, 15, 16 that meant meningeal inflammation could trigger a unified pro‐ and anti‐inflammatory response in viral infections.17, 18, 19, 20 Cytokine profiling could contribute to localize the site of immune activation in viral infections. This evidence concerns the gene CSF2 and viral infectious disease.