Moreover, Myc‐overexpression induced UPR in Drosophila and PERK was required for an increased autophagy‐dependent cell growth.13 Hypoxia also activated PERK transcription which induced UPR‐dependent upregulation of autophagy.14 Thus, autophagy can protect tumor cells by mediating the c‐Myc–PERK‐UPR axis. This evidence concerns the gene EIF2AK3 and neoplasm.