The regulation of mTORC1 by p62 promoted cell proliferation in vitro and tumor growth in vivo.15 mTOR also regulated V‐ATPase, a critical component of the late endosome/lysosome, through a transcription factor EB (TFEB) in renal cancer.16 That is to say, there is a regulatory network linking an oncogenic transcription factor TFEB to mTORC1 and lysosomal biogenesis, which allows autophagy to act as an oncosuppressor or oncopromoter. This evidence concerns the gene TFEB and neoplasm.