The regulation of mTORC1 by p62 promoted cell proliferation in vitro and tumor growth in vivo.15 mTOR also regulated V‐ATPase, a critical component of the late endosome/lysosome, through a transcription factor EB (TFEB) in renal cancer.16 That is to say, there is a regulatory network linking an oncogenic transcription factor TFEB to mTORC1 and lysosomal biogenesis, which allows autophagy to act as an oncosuppressor or oncopromoter. The gene discussed is MTOR; the disease is neoplasm.