Autophagy usually occurs in tumor cells distal to blood vessels to support tumor cell survival in hypoxic regions.22 The hypoxia inducible transcription factor 1α (Hif‐1α) drives the transcription of hundreds of genes that promote erythropoiesis and angiogenesis and decrease mitochondrial biogenesis and respiration, thus diminishing deleterious effects caused by O2 deficiency. Here, HIF1A is linked to neoplasm.