PRSS12 and sarcopenia: The degree of release of CAF into the blood is proportional to the increase in neurotrypsin activity and the reduction in neuromuscular junction strength.51 In older adults with sarcopenia, serum concentrations of CAF have been shown to be elevated compared with adult controls of the same age.54, 55 Because this process seems to be triggered by cellular damage mediated by oxidative stress,56 we expected a higher peripheral CAF concentration in patients with a lower endogenous antioxidant capacity, that is to say, in sarcopenic subjects.