Importantly, the difference between wtTNF and CD13‐AFR cannot be explained by differential induction of IFN‐γ, since mTNF is as efficient in inducing tumor necrosis in IFN‐γR−/− mice as in wt mice, indicating that its antitumor effect is independent of IFN‐γ (Fig EV2B). Here, IFNGR1 is linked to neoplasm.