This is likely critical in trafficking of antigen‐presenting cells into lymph node and cancer tissues as antigen presentation to effector cells is strictly regulated by secretory cytokines and chemokines.32 Unexpectedly, there was no obvious difference in M1/M2 cytokine profile between wt and lamin A/C‐deficient CD11b+Ly6C+ cells as both IL‐12 (M1 cytokine) and IL‐4 (M2 cytokine) were decreased in lamin A/C‐deficient cells (Figure S4A). This evidence concerns the gene IL4 and cancer.