Although the roles of Stab2 in atherosclerosis have yet to be validated, our results suggest that the DBA-specific genomic alterations restrict Stab2 functions and cause the accumulation of HA, which supports the idea that Stab2DBA potentially contributes to protection against early atherosclerosis, since HA infusion in animals is atheroprotective by reducing infiltration of immune cells into plaques (Beldman et al. 2017). Here, RPS19 is linked to atherosclerosis.