HCRT and depressive disorder: The upregulated genes include Avp, associated with schizophrenia (98) and depression (99, 100) (Fig. 4C); Hcrt, related to anxiety, depression, and pain (101, 102) (Fig. 5B); and Pcsk1n, which is predictive of Alzheimer’s disease via association with the amyloid antiaggregant protein, proSAAS (103) (Fig. 2C).