DIO2 and depressive disorder: Those genes include Hcrt (metabolic disease, anxiety, depression, and pain), Gal (metabolic disease, Alzheimer, anxiety, depression, and pain), Nr4a2 (inflammation, Parkinson disease, and schizophrenia), Mt1 (metabolic disease, inflammation, and depression), Dio2 (metabolic disease, inflammation, anxiety, and depression), Ghsr (metabolic disease, inflammation, pain, and Parkinson disease) (Fig. 5B) and Hdc (metabolic disease and anxiety), Avp (metabolic disease, anxiety, and pain), Oxt (metabolic disease, inflammation, anxiety, autism, depression, and pain) (Fig. 4B,C).