It was reported that NSD1 was more mutated in laryngeal and pharyngeal squamous cell carcinoma (L/P-SCC) than in OC-SCC [32], and given the role of NSD1 as a chromatin modifier, these mutations could contribute to cancer formation through a combination of rare germline variants and somatic loss-of-heterozygosity (LOH) [33]. Here, NSD1 is linked to pharyngeal squamous cell carcinoma.