CTSB and Alzheimer disease: Lysosomal proteins, such as cathepsins B and D and lysosome-associated membrane protein 1 (LAMP-1) were identified in brain EVs, suggesting that autophagic-lysosomal dysfunction of neurons in AD may result in vesicular lysosomal exocytosis (Andrews, 2000; Ihara et al., 2012; Urbanelli et al., 2013).