Evaluation of UBQLN4 expression in normal liver cell lines (Chang liver and LO2) and HCC cell lines (HepG2, SMMC-7721, SK-Hep-3B, HCC-LM3 and MHCC-97H) was conducted to investigate the role of UBQLN4 in HCC cell progression. This evidence concerns the gene UBQLN4 and hepatocellular carcinoma.