BRCA1 and hereditary sensory and autonomic neuropathy: In BRCA1, 89.4% of missense variants submitted to ClinVar are classified as VUS and only 4.5% as pathogenic.19 A total of 89 pathogenic + likely pathogenic (P + LP), 119 benign + likely benign (B + LB), and 1759 VUS were included in the analysis, after excluding variants with CIP or no assertion criteria provided (Supplementary Data File).