As shown in Fig. 6a–c, serum-albumin extravasation into brain parenchyma was ~5-fold higher in mice with ischemic stroke than in sham-operated mice (p < 0.05, n = 5–6), suggesting that tMCAO/reperfusion induced disruption of BBB integrity in ischemic brains. The gene discussed is ALB; the disease is ischemic stroke.