KREMEN1 and hand, foot and mouth disease: Indeed HFMD viruses can be divided into four groups depending on their receptor usage (Supplementary Fig. 1): EV-A71, CV-A7, CV-A14 and CV-A16 use SCARB2 (scavenger receptor class B member 2, also named lysosomal integral membrane protein-2, LIMP-2)15,16, Coxsackie viruses A2-6, A8, A10 and A12 use KREMEN1 (kringle (KR) containing transmembrane protein 1; KRM1)17, Coxsackie viruses B1-3 and B5 use CAR (Coxsackievirus and adenovirus receptor) and EV-E3, E6, E7, E11 and E12 use DAF/FcRn (decay-accelerating factor/neonatal Fc receptor)2,18,19.