Meanwhile, the PiD_P1 was mainly detected by 3R tau antibody (Fig. 2f, g), suggesting that distinct tauopathy strains prefer to recruit the corresponding tau isoforms seen in AD, PSP, CBD, and PiD into the corresponding tau aggregates in the 6hTau mice, confirming this process is dependent upon the tau strain itself. Here, MAPT is linked to Alzheimer disease.