As shown in Supplementary Fig. 6, there were no significant differences in astrogliosis, microgliosis and oligodendrogliosis in CBD/PSP-6hTau mice compared to AD-6hTau or PiD-6hTau mice, suggesting the glial tau pathologies predominantly induced by CBD/PSP-tau may not be due to their specific glial activation. Here, MAPT is linked to Alzheimer disease.