IHC using 3R- or 4R-specific anti-tau antibodies showed the induced tau pathologies in 6hTau mice recapitulated the isoform compositions in the original human tau strains since injection of AD-tau from two AD cases induced tau pathologies comprised of both 3R and 4R tau, while tau extracts from two PiD cases predominantly induced 3R tau pathologies. This evidence concerns the gene MAPT and pelvic inflammatory disease.