Neurodegenerative tauopathies, including Alzheimer’s disease (AD), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and Pick’s disease (PiD), are major neurodegenerative diseases characterized by the deposition of aggregated tau proteins in neurons, as well as glia in CBD, PSP, and PiD. This evidence concerns the gene MAPT and Alzheimer disease.