MAPT and tauopathy: To determine if distinct tau strains from diverse human tauopathies studied here can be recapitulated in mice, we propagated the tau strains in vivo by intracerebrally injecting 1 μg/site of different human brain-derived tau strains (designated as AD_P0-, PiD_P0-, CBD_P0-, PSP_P0-tau) into the hippocampus and overlying cortex of 6hTau mice.