Similar to the pattern observed for granzyme B, IL-12 production within the tumor microenvironment of the AA+anti-PD1 group (0.86% ± 0.24) was significantly higher than anti-PD1 alone (0.3% ± 0.08, t test, P = 0.03), AA alone (0.23% ± 0.07, t test, P = 0.019), and vehicle (0.29% ± 0.12, t test, P = 0.035) (Fig. 6B). This evidence concerns the gene GZMB and neoplasm.