LINC02747 and breast cancer: CCVs at 11q13 fall within an estrogen-regulated enhancer of two lncRNAs called CUPID1 and CUPID2. In heterozygous breast cancer cell lines, we showed allele-specific chromatin looping between the enhancer and the CUPID1/2 bidirectional promoter suggesting CCVs reduce their expression by inhibiting chromatin looping [18].