ESR1 and breast cancer: Genetic fine-mapping of 12q24 identified at least four independent signals [2, 5] (listed in Additional file 2: Table S14); signal 1 (seven CCVs), signal 2 (one CCV), and signal 4 (six CCVs) were more strongly associated with ER+ tumors, whereas signal 3 (eight CCVs) was associated with both ER+ and ER− breast cancer (Additional file 2: Table S14).